Zinc finger, ZPR1

Description

PFAM: The zinc-finger protein ZPR1 is localised to the cytoplasm in quiescent cells; in proliferating cells treated with EGF or with other mitogens it accumulates in the nucleolus. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes. These move into the nucleus, localising particularly at the nucleolus. ZPR1 is thought to be involved in pre-ribosomal RNA expression. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion.

References:


1) Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503 PubMed
2) Gangwani, L1; Mikrut, M; Galcheva-Gargova, Z; Davis, RJ. 1998. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. J Cell Biol 143(6):1471-84 PubMed
3) Galcheva-Gargova, Z; Gangwani, L; Konstantinov, KN; Mikrut, M; Theroux, SJ; Enoch, T; Davis RJ. 1998. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Mol Biol Cell 9(10):2963-71 PubMed


Summary

Name: Zinc finger, ZPR1
Class: TR
Number of species containing the TAP: 111
Number of available proteins: 178

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:


(Domain names are clickable)


Phylogenetic tree for Archeaplastida:

To view the tree click here.



TAP distribution:

The following table shows the distribution of Zinc finger, ZPR1 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation
071.5211.09

List of species containing Zinc finger, ZPR1 sorted by kingdomcladesupergrouporderfamily:

hide all | show all

expand kingdom Archaeplastida (181 proteins in 111 species)
select all | unselect | select genome only

A list of species letter codes included in the protein names can be found here (opens in new tab).


Impressum