Coactivator p15

Description

Kretzschmar et al. (1994): Functional deletion analyses revealed a bipartite structure of p15 comprising an amino-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain. We provide evidence that activity of p15 is controlled by protein kinases that target the regulatory domain. Structural and functional similarities, including sequence homology to domains essential for cofactor function, cofactor activity, promiscuity with respect to transcriptional activators, and interactions with components of the basal transcription machinery, relate this novel cellular cofactor to viral immediate-early transcriptional regulators.

References:


Kretzschmar, M; Kaiser, K; Lottspeich, F; Meisterernst, M. 1994. A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell 78(3):525-34 PubMed


Summary

Name: Coactivator p15
Class: TR
Number of species containing the TAP: 117
Number of available proteins: 304

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:


(Domain names are clickable)


Phylogenetic tree for Archeaplastida:

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TAP distribution:

The following table shows the distribution of Coactivator p15 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation
092.5521.69

List of species containing Coactivator p15 sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (314 proteins in 117 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).


Impressum