Griess et al. (1993): HMG boxes were initially identified as DNA-binding domains of the human RNA polymerase I (pol I) transcription factor hUBF and the animal high-mobility-group (HMG) protein family HMG1.


1) Grasser, KD; Teo, SH; Lee, KB; Broadhurst, RW; Rees, C; Hardman, CH; Thomas, JO. 1998. DNA-binding properties of the tandem HMG boxes of high-mobility-group protein 1 (HMG1). Eur. J. Biochem. 253(3):787-95 PubMed
2) Griess, EA; Rensing, SA; Grasser, KD; Maier, UG; Feix, G. 1993. Phylogenetic relationships of HMG box DNA-binding domains. J. Mol. Evol. 37(2):204-10 PubMed
3) Wissmüller, S; Kosian, T; Wolf, M; Finzsch, M; Wegner, M. 2006. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 34(6):1735-44 PubMed


Name: HMG
Class: TR
Number of species containing the TAP: 113
Number of available proteins: 1210

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

To view the tree click here.

TAP distribution:

The following table shows the distribution of HMG over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing HMG sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (1225 proteins in 113 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).