Koschubs et al. (2009): Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules.


Koschubs, T; Seizl, M; Lariviere, L; Kurth, F; Baumli, S; Martin, DE; Cramer, P. 2009. Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J. 28(1):69-80 PubMed


Name: Med7
Class: TR
Number of species containing the TAP: 106
Number of available proteins: 159

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

To view the tree click here.

TAP distribution:

The following table shows the distribution of Med7 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing Med7 sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (162 proteins in 106 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).