Med7

Description

Koschubs et al. (2009): Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules.

References:


Koschubs, T; Seizl, M; Lariviere, L; Kurth, F; Baumli, S; Martin, DE; Cramer, P. 2009. Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J. 28(1):69-80 PubMed


Summary

Name: Med7
Class: TR
Number of species containing the TAP: 106
Number of available proteins: 159

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:


(Domain names are clickable)


Phylogenetic tree for Archeaplastida:

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TAP distribution:

The following table shows the distribution of Med7 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation
0111.3611.25

List of species containing Med7 sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (162 proteins in 106 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).


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