Rel
Description
| PFAM: | The Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, which includes NF-κB, NFAT, among others. The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. The C-terminal dimerization domain contains the site for interaction with I-kappaB. |
References:
| 1) | Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503 PubMed |
| 2) | Müller, CW; Rey, FA; Sodeoka, M; Verdine, GL; Harrison, SC. 1995. Structure of the NF-kappa B p50 homodimer bound to DNA. Nature. 373(6512):311-7 PubMed |
Summary
| Name: | Rel |
|---|---|
| Class: | TF |
| Number of species containing the TAP: | 0; it was not found in Archaeplastida |
The colour code corresponds to the rules for the domains:
should be contained
should not be contained
should not be contained
Domain rules:
(Domain names are clickable)