Marmorstein (2003): The methylation of lysine residues on histone tails is catalyzed by proteins containing a conserved SET domain. A recent flurry of structures of SET domain proteins has revealed a new protein fold and a scaffold for understanding catalysis and substrate binding by these enzymes. The prospect that histone methylation might form an epigenetic code and the implicated involvement of SET domain proteins in cancer assures that structure-function studies of these enzymes will continue until their detailed mechanism of action is determined.


1) Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503 PubMed
2) Marmorstein, R. 2003. Structure of SET domain proteins: a new twist on histone methylation. Trends Biochem. Sci. 28(2):59-62 PubMed


Name: SET
Class: TR
Number of species containing the TAP: 119
Number of available proteins: 4833

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

To view the tree click here.

TAP distribution:

The following table shows the distribution of SET over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing SET sorted by kingdomcladesupergrouporderfamily:

hide all | show all

expand kingdom Archaeplastida (4909 proteins in 119 species)