BES1

Description

Yin et al. (2005): Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

References:


1) Li, L; Deng, XW. 2005. It runs in the family: regulation of brassinosteroid signaling by the BZR1-BES1 class of transcription factors. Trends Plant Sci. 10(6):266-8 PubMed
2) Vert, G; Nemhauser, JL; Geldner, N; Hong, F; Chory, J. 2005. Molecular mechanisms of steroid hormone signaling in plants. Annu. Rev. Cell Dev. Biol. 21:177-201 PubMed
3) Yin, Y; Vafeados, D; Tao, Y; Yoshida, S; Asami, T; Chory, J. 2005. A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. Cell 120(2):249-59 PubMed


Summary

Name: BES1
Class: TF
Number of species containing the TAP: 98
Number of available proteins: 814

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:


(Domain names are clickable)


Phylogenetic tree for Archeaplastida:

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TAP distribution:

The following table shows the distribution of BES1 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation
0296.9375.3

List of species containing BES1 sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (825 proteins in 98 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).


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